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Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis.

Herrod PJJ, Kwok AT, Lobo DN.

BJS Open 2022; 6: zrac100.

Eight RCTs including 3203 participants were analyzed. Early optimism about the benefits of antibiotic therapy were tempered in this analysis by reduced treatment efficacy compared with appendicectomy, higher readmission rate, and no advantage in duration of stay at index admission.

Comment: Antibiotic treatment for appendicitis has a place, but not as standard therapy.

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