Randomized clinical trials

The randomized clinical trials section is produced following a review of the content of the best surgical journals published in English worldwide. The section editor is Jonothan Earnshaw, former director of the BJS Academy and Consultant Vascular Surgeon at Gloucestershire Hospitals NHS Foundation Trust, UK, in conjunction with editor assistant Jenny Moon.

Impact of a patient-centered program for low anterior resection syndrome: A multicenter, single-blinded, randomized controlled trial

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20 November 2025

Randomized clinical trials

Impact of a patient-centered program for low anterior resection syndrome: A multicenter, single-blinded, randomized controlled trial

Recurrence rate and mesh bulging are reduced with primary fascial closure in ventral hernia repair: the PROSECO randomized clinical trial

Quilt technique after mastectomy: stepped-wedge randomized cluster trial showing superior textbook outcome and reduced healthcare utilization

Precision exercise effect on fatigue and function in lung cancer surgery: A randomized clinical trial

Indocyanine green fluorescence imaging in prevention of colorectal anastomotic leakage: A randomized clinical trial.

Covered versus uncovered endoluminal stenting in the acute management of obstructing colorectal cancer in the palliative setting: randomized clinical trial (CReST2)

The NEON (Nerve rEpair Or Not) trial: a randomized controlled trial of microsurgical repair versus nerve alignment for digital nerve injury

Three-year survival outcomes of patients with enhanced recovery after surgery versus conventional care in laparoscopic distal gastrectomy: The GISSG1901 randomized clinical trial

Thyroidectomy with or without postoperative radioiodine for patients with low-risk differentiated thyroid cancer in the UK (IoN): a randomised, multicentre, non-inferiority trial

Surgery versus corticosteroid injection for carpal tunnel syndrome (DISTRICTS): an open-label, multicentre, randomised controlled trial

The impact of psychological prehabilitation on surgical outcomes: A meta-analysis and meta-regression

Robotic vs laparoscopic surgery for middle and low rectal cancer: The REAL randomized clinical trial

Perioperative durvalumab in gastric and gastroesophageal junction cancer.

Sigmoid resection vs conservative treatment after diverticulitis: prespecified 4-year analysis of the LASER randomized clinical trial

Role of preoperative antibiotic treatment while awaiting appendectomy: The PERFECT-Antibiotics randomized clinical trial

Structured exercise after adjuvant chemotherapy for colon cancer

A randomized trial of acute normovolemic hemodilution in cardiac surgery

Chemoradiotherapy and local excision vs total mesorectal excision in T2-T3ab, N0, M0 rectal cancer: the TAUTEM randomized clinical trial

Paravertebral versus EPidural analgesia in Minimally invasive Esophageal ResectioN (PEPMEN): a randomized controlled multicenter trial

Identification and categorization of technical errors and hazard zones of robotic versus laparoscopic total gastrectomy for gastric cancer: a single-center prospective randomized controlled study

Improving empiric antibiotic selection for patients hospitalized with abdominal infection: The INSPIRE 4 cluster randomized clinical trial

Comparison of postoperative analgesic effects of ultrasound-guided intercostal nerve block and transversus abdominis plane block in patients undergoing laparoscopic cholecystectomy: randomized clinical trial

Effectiveness of a patient decision aid for women considering post-mastectomy breast reconstruction: randomized controlled trial

Comparison of catheter wound infusion, intrathecal morphine, and intravenous analgesia for postoperative pain management in open liver resection: randomized clinical trial