Randomized clinical trials

The randomized clinical trials section is produced following a review of the content of the best surgical journals published in English worldwide. The section editor is Jonothan Earnshaw, Director of the BJS Academy and Consultant Vascular Surgeon at Gloucestershire Hospitals NHS Foundation Trust, UK.

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RCT of the Month

Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial

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6 March 2025

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Decellularized dermis allograft for the treatment of venous leg ulceration: the DAVE RCT

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2 May 2025

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Comparing the efficacy and safety of thromboprophylaxis with enoxaparin versus normal saline after liver transplantation: randomized clinical trial

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2 May 2025

Vascular HPB Transplantation

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Impact of pre-compression versus non-compression before parenchyma transection in left-sided pancreatic resection on the rate of clinically relevant pancreatic fistula: multicentre randomized clinical trial

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2 May 2025

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Gastric partitioning versus gastrojejunostomy for gastric outlet obstruction due to unresectable gastric cancer: randomized clinical trial

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2 May 2025

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Axillary surgery versus no-axillary staging in T1N0 breast cancer: 20-year follow-up of the INT 09/98 randomized clinical trial

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2 May 2025

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Onlay mesh versus suture repair for smaller umbilical hernias in adults—early results from SUMMER trial: randomized clinical trial

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2 May 2025

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Perioperative chemotherapy or preoperative chemoradiotherapy in esophageal cancer

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22 April 2025

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Intravenous lidocaine for gut function recovery in colonic surgery. A randomized clinical trial

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22 April 2025

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Annual versus less frequent mammographic surveillance in people with breast cancer aged 50 years and older in the UK (Mammo-50): a multicentre, randomised, phase 3, non-inferiority trial

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22 April 2025

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Long-term results of 2-stage Turnbull-Cutait pull-through coloanal anastomosis for low rectal cancer

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17 February 2025

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Neoadjuvant nivolumab and ipilimumab in resectable stage III melanoma

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17 February 2025

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Extent of lymphadenectomy for surgical management of right-sided colon cancer: the randomized phase III RELARC Trial

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17 February 2025

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Open retromuscular Sugarbaker vs keyhole mesh placement for parastomal hernia repair

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17 February 2025

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Parastomal hernia prevention using funnel-shaped intra-abdominal mesh compared to no mesh. The Chimney randomized clinical trial

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17 February 2025

Colorectal Hernia

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TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and complex or multivessel coronary disease (TCW): an international, multicentre, prospective, open-label, non-inferiority, randomised controlled trial

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17 February 2025

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Preoperative chemoradiotherapy for resectable gastric cancer

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20 January 2025

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Reductions in recurrence in women with early breast cancer entering clinical trials between 1990 and 2009: a pooled analysis of 155 746 women in 151 trials

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20 January 2025

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Screening for Helicobacter pylori to prevent gastric cancer: A pragmatic randomized clinical trial

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20 January 2025

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Restrictive strategy vs usual care for cholecystectomy in patients with abdominal pain and gallstones: 5-year follow-up of the SECURE randomized clinical trial

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20 January 2025

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Tranexamic acid in patients undergoing liver resection: The HeLiX randomized clinical trial

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20 January 2025

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Effects of the superior mesenteric artery approach versus the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial.

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6 January 2025

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Continuous preperitoneal versus thoracic epidural analgesia in open pancreatoduodenectomy: randomized clinical trial

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6 January 2025

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Long-term follow-up of the conventional versus no-touch isolation technique for resection of primary colon cancer (JCOG1006): randomized clinical trial

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6 January 2025

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