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Surgical Trials

Dedicated to raising the profile of clinical trials in surgery. Surgical trials offers the busy surgeon with an update of important clinical trials being developed or in progress in surgery.
Focusing on the rationale and content of new surgical trials, it gives surgeons and trainees the opportunity to learn what interventions are being evaluated and why and how they may contribute.
Perf-Act BreCon: A Prospective Case-control Study to Compare Tissue <underline>Perf</underline>usion between Retr<underline>A</underline>ctors and Non-retractors during Immediate <underline>Bre</underline>ast Re<underline>Con</underline>struction

Perf-Act BreCon: A Prospective Case-control Study to Compare Tissue Perfusion between RetrActors and Non-retractors during Immediate Breast ReConstruction

Amit Agrawal, Alex Azevado

5 February 2026
CLARITY: SurgiCaL educAtion to Reduce IncorrecT care pathwaYs and enhance patient outcomes in right iliac fossa pain

CLARITY: SurgiCaL educAtion to Reduce IncorrecT care pathwaYs and enhance patient outcomes in right iliac fossa pain

18 December 2025
Type B dissections: keeping it “uncomplicated” in a complicated world

Type B dissections: keeping it “uncomplicated” in a complicated world

Bianca Biersteker, Joost van der Vorst, Jacob Budtz-Lilly

17 December 2025
PROTECT: a national perioperative platform trial to improve surgical outcomes

PROTECT: a national perioperative platform trial to improve surgical outcomes

16 December 2025
Targeting intratumoral microbiome: the MONARCH Trial takes aim at anaerobes in rectal cancer

Targeting intratumoral microbiome: the MONARCH Trial takes aim at anaerobes in rectal cancer

Taylor M. Neilson, Laurence P. Diggs, Norman J. Galbraith, Jaganmurugan Ramamurthy, Neal Bhutiani, Ian Z. Hu, Arvind N. Dasari, Michael J. Overman, Scott E. Kopetz, Wei Qiao, Pranoti Sahasrabhojane, Vivian Orellana, Brian K. Bednarski, Montserrat Guraieb-Trueba, Ramy S. Behman, Ashish Damania, Nadim J. Ajami, Yan Wang, Mingxuan Xu, George J. Chang, Jennifer A. Wargo, Susan Bullman, Christopher D. Johnston, Y. Nancy You, Michael G. White

8 December 2025
Pain and reward in emergency surgery trials

Pain and reward in emergency surgery trials

Mark Edwards

8 December 2025
IMPROVE-AD: Randomized trial for uncomplicated Type B Aortic Dissection

IMPROVE-AD: Randomized trial for uncomplicated Type B Aortic Dissection

27 October 2025
THrough knee AMputation’s impact on quality of Life compared to abovE knee ampuTation: THE HAMLET TRIAL

THrough knee AMputation’s impact on quality of Life compared to abovE knee ampuTation: THE HAMLET TRIAL

Sophie James , Sean Pymer , Catherine Arundel, Laura Doherty, Tom Davill, George Smith

20 October 2025
Closing the treatment gap in knee osteoarthritis — the GEKO trial begins

Closing the treatment gap in knee osteoarthritis — the GEKO trial begins

Dr Raman Uberoi, Dr Anjali Shah, Dr Bhavisha Patel, Dr Loretta Davies, Professor Andrew Price, GEKO study group

16 October 2025
THRIVE Trial: Advancing Thromboprophylaxis in Superficial Venous Intervention

THRIVE Trial: Advancing Thromboprophylaxis in Superficial Venous Intervention

Sarah Whittley

3 October 2025
The NEON trial: nerve repair vs. alignment for digital nerve injuries

The NEON trial: nerve repair vs. alignment for digital nerve injuries

Justin C R Wormald, MRCS, DPhil

4 September 2025
LOLIPOP trial: Long-term outcomes of lidocaine for post-operative chronic post-surgical pain

LOLIPOP trial: Long-term outcomes of lidocaine for post-operative chronic post-surgical pain

Chloe Beard, Leah Fleming, Annie Thomas, Rachel Brierley