BJS Academy>Randomized clinical ...>Sacral neuromodulati...
Sacral neuromodulation versus conservative treatment for refractory idiopathic slow-transit constipation. The randomized clinical No.2-Trial.
30 August 2024
Randomized clinical trials Colorectal
Related articles
Morbidity after mechanical bowel preparation and oral antibiotics prior to rectal resection. The MOBILE2 randomized clinical trial.
Koskenvuo L, Lunkka P, Varpe P, Hyoty M, Satokari R, Haapamaki C
JAMA Surg 2024; 159: 606-614.
RCT: Morbidity after mechanical bowel preparation and oral antibiotics prior to rectal resection. The MOBILE2 randomized clinical trial. by BJS AcademyIn this study that included 565 procedures, the addition of oral antibiotics reduced the rate of surgical site infections (odds ratio 0.45, 95 per cent confidence interval 0.27 to 0.77) and anastomotic leaks (0.39, 0.21 to 0.72).
Comment: The authors suggest this should be the standard of care.
Pyridostigmine to reduce the duration of postoperative Ileus after colorectal surgery (PyRICo-RCT): randomized clinical trial.
Traeger L, Bedrikovetski S, Fitzsimmons T, Nguyen T-M, Moore JW, Lewis M
Br J Surg 2024; 111: znae121.
Pyridostigmine 60mg given orally twice daily after surgery reduced the duration of ileus by one day, measured by the GI-2 tool (P=0.015) in this study that included 130 patients, but did not affect the duration of hospital stay.
Comment: Apart from speeding return of bowel function, it is not clear what the benefit is overall.
Impact of small-bite (5 mm) fascial closure on the incidence of incisional hernia following open colorectal cancer surgery: randomized clinical trial
Ozcan C, Colak T, Turkmenoglu O, Berkesoglu M, Ertas E.
Br J Surg 2024; 111: znae189.
Use of the small bite technique reduced the rate of surgical site infection (18 versus 31 per cent, P=0.03) and the incisional hernia rate after two years (9 versus 31 per cent, P<0.001).
Comment: Small bites strongly recommended.
Copied!