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Morbidity after mechanical bowel preparation and oral antibiotics prior to rectal resection. The MOBILE2 randomized clinical trial.

25 September 2024
Randomized clinical trials Colorectal
Koskenvuo L, Lunkka P, Varpe P, Hyoty M, Satokari R, Haapamaki C et al.

JAMA Surg 2024; 159: 606-614.  

RCT: Morbidity after mechanical bowel preparation and oral antibiotics prior to rectal resection. The MOBILE2 randomized clinical trial. by BJS Academy

In this study that included 565 procedures, the addition of oral antibiotics reduced the rate of surgical site infections (odds ratio 0.45, 95 per cent confidence interval 0.27 to 0.77) and anastomotic leaks (0.39, 0.21 to 0.72).

Comment: The authors suggest this should be the standard of care.

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rct281
Randomized clinical trials
Randomized clinical trials
Colorectal
Morbidity after mechanical bowel preparation and oral antibiotics prior to rectal resection. The MOBILE2 randomized clinical trial.
Koskenvuo L, Lunkka P, Varpe P, Hyoty M, Satokari R, Haapamaki C et al.
25092024
JAMA Surg 2024; 159: 606-614.  
RCT: Morbidity after mechanical bowel preparation and oral antibiotics prior to rectal resection. The MOBILE2 randomized clinical trial. by BJS Academy
In this study that included 565 procedures, the addition of oral antibiotics reduced the rate of surgical site infections (odds ratio 0.45, 95 per cent confidence interval 0.27 to 0.77) and anastomotic leaks (0.39, 0.21 to 0.72).
Comment: The authors suggest this should be the standard of care.
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Published on: 25 September 2024
Article ID: rct281

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