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Ondansetron for low anterior resection syndrome (LARS). A double-blind, placebo-controlled, cross-over, randomized study.


Popeskou SG, Roesel R, Faes S, Vanoni A, Galafassi J, di Tor Vajana AF et al.

Ann Surg 2024; 279: 196-202.

Thirty-four patients with symptomatic low anterior resection syndrome (LARS) were included. Those randomized to Ondansetron first had improved LARS scores, whereas those who had Ondansetron second, tended to have deteriorating scores. Treatment was safe.

Comment: Good treatment for an unpleasant condition.

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