Martling A, Myrberg H, Nilbert M, Grönberg H, Granath F, Eklund M et al, for the ALASCCA Study Group.
N Engl J Med 2025; 393: 1051-1064.
Around one third of patients with colorectal cancer have altered P13K pathway genes. In a study of 1103 patients, 160mg aspirin a day reduced recurrence rate after three years, both in patients with group A alterations (7.7 versus 14.1 per cent, P=0.04) and group B alterations (7.7 versus 16.8 per cent).
Comment: Worth identifying and treating these individuals.
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