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Aspirin after completion of standard adjuvant therapy for colorectal cancer (ASCOLT): an international, multicentre, phase 3, randomised, double-blind, placebo-controlled trial

10 December 2025
Colorectal
BJSA
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
Chia JWK, Segelov E, Deng Y, Ho GF, Wang W, Han S et al.
Lancet Gastrohepatol 2025; 10: 198-209.
Some 1550 patients were randomly allocated 200mg Aspirin per day or placebo for three years, and followed for five years. Disease-free survival was 77 per cent in the aspirin group versus 74.8 per cent in controls, P=0.38.
Comment: An aspirin a day doesn’t keep recurrence away.
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