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Neoadjuvant chemotherapy with CAPOX versus chemoradiation for locally advanced rectal cancer with uninvolved mesorectal fascia (CONVERT): initial results of a Phase III Trial.

Mei W-J, Wang X-Z, Li Y-F, Sun Y-M, Yang C-K, Lin J-Z et al.

Ann Surg 2023; 277: 557-564.

In this study that included 589 procedures, neoadjuvant chemotherapy with radiotherapy had similar effect on complete pathological response and downstaging. Radiotherapy increase the risk of needing an ileostomy: 63.6 versus 52.2 per cent, P= 0.008.

Comment: The late outcomes of this trial will reveal whether additional radiotherapy is worthwhile.

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