This website uses cookies to improve your experience.

Cookie policy

Neoadjuvant chemoradiotherapy with radiation dose escalation with contact x-ray brachytherapy boost or external beam radiotherapy boost for organ preservation in early cT2–cT3 rectal adenocarcinoma (OPERA): a phase 3, randomised controlled trial


Gerard J-P, Barbet N, Schiappa R, Magne N, Martel I, Mineur L et al, on behalf of the ICONE group.

Lancet Gastrohepatol 2023; 8: 356-367.

This study explored whether a radiotherapy booster was beneficial in 148 patients with a complete response to neoadjuvant chemoradiotherapy. Three-year preservation of the rectum was more likely after contact brachytherapy (81 per cent) versus 59 per cent for booster external beam radiotherapy, P=0.0026. The effect was greatest for tumours <3cm in diameter.

Comment: Management of rectal tumours with the aim to avoid ablative surgery is evolving.

Read paper

Academy


Part of the charitable activity of the Foundation, BJS Academy is an online educational resource for current and future surgeons.

The Academy is comprised of five distinct sections: Continuing surgical education, Young BJS, Cutting edge, Scientific surgery and Surgical news. Although the majority of this is open access, additional content is available to BJS subscribers and strategic partners.

Discover the Academy
Surgeon Training & Surgeons in Surgery