Thyroidectomy with or without postoperative radioiodine for patients with low-risk differentiated thyroid cancer in the UK (IoN): a randomised, multicentre, non-inferiority trial

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Thyroidectomy with or without postoperative radioiodine for patients with low-risk differentiated thyroid cancer in the UK (IoN): a randomised, multicentre, non-inferiority trial

15 October 2025

Endocrine

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BJS-2025-0517

Randomized clinical trials

Endocrine

Thyroidectomy with or without postoperative radioiodine for patients with low-risk differentiated thyroid cancer in the UK (IoN): a randomised, multicentre, non-inferiority trial

15102025

Mallick U, Newbold K, Beasley M, Garcez K, Wadsley J, Johnson SJ et al.

Lancet 2025; 406: 52-62.

This study that included 504 patients with complete resection of low grade thyroid cancer did not benefit from additional radioiodine ablation. Five-year recurrence-free survival was similar: 96.3% ablation vs 97.9% in controls.

Comment: Conclusive trial showing radioiodine ablation is unnecessary in these patients.

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Published on: 15 October 2025

Article ID: BJS-2025-0517

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Thyroidectomy with or without postoperative radioiodine for patients with low-risk differentiated thyroid cancer in the UK (IoN): a randomised, multicentre, non-inferiority trial

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Thyroidectomy with or without postoperative radioiodine for patients with low-risk differentiated thyroid cancer in the UK (IoN): a randomised, multicentre, non-inferiority trial

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