Thyroidectomy with or without postoperative radioiodine for patients with low-risk differentiated thyroid cancer in the UK (IoN): a randomised, multicentre, non-inferiority trial

Koh J-M, Song K, Kwak MK, Suh S, Kim B-J, Sung T-Y et al.

Ann Surg 2024; 279: 945-952.

This study included 132 patients with an asymptomatic incidental adrenaloma, but raised serum cortisol. Adrenalectomy improved weight control and diabetes control (both P=0.002) compared with the control group.

Comment: Good evidence upon which to base treatment in these patients.

Schiavone D, Crimì F, Cabrelle G, Pennelli G, Sacchi D, Mian C et al.

Br J Surg 2024; 111: znae196.

In this study that included 56 patients, preoperative use of Lugol’s significantly reduced T3 and T4 levels, but had no effect on clinical outcomes, including blood loss (80.5 versus 94ml with no Lugols’s) and duration of surgery.

Comment: Is the trial large enough to wave goodbye to Lugol’s?

Leboulleux S, Bournaud C, Chougnet CN, Zerdoud S, Al Ghuzlan, Catargi B et al.

N Engl J Med 2022; 386:923-932.

In this study that included 730 patients, there was no difference in structural or functional outcomes up to three years.

Comment: Too early to conclude much, but a good sized group for longer follow-up.