Adrenalectomy improves body weight, glucose, and blood pressure control in patients with mild autonomous cortisol secretion. Results of a randomized controlled trial by the Co-work Of Adrenal Research (COAR) Study.

Schiavone D, Crimì F, Cabrelle G, Pennelli G, Sacchi D, Mian C et al.

Br J Surg 2024; 111: znae196.

In this study that included 56 patients, preoperative use of Lugol’s significantly reduced T3 and T4 levels, but had no effect on clinical outcomes, including blood loss (80.5 versus 94ml with no Lugols’s) and duration of surgery.

Comment: Is the trial large enough to wave goodbye to Lugol’s?

Leboulleux S, Bournaud C, Chougnet CN, Zerdoud S, Al Ghuzlan, Catargi B et al.

N Engl J Med 2022; 386:923-932.

In this study that included 730 patients, there was no difference in structural or functional outcomes up to three years.

Comment: Too early to conclude much, but a good sized group for longer follow-up.

Ahn J-H, Kwak JH, Yoon SG, Yi JW, Yu HW, Kwon H et al.

Surgery 2022; 171: 182-189.

Central lymph node dissection improved the yield of positive nodes in this study of 101 procedures, without affecting complication rates. No patient had a recurrence up to four years after surgery.

Comment: This study is too small to provideanswers in the long term.