Adrenalectomy improves body weight, glucose, and blood pressure control in patients with mild autonomous cortisol secretion. Results of a randomized controlled trial by the Co-work Of Adrenal Research (COAR) Study.

Ann Surg 2024; 279: 945-952.

This study included 132 patients with an asymptomatic incidental adrenaloma, but raised serum cortisol. Adrenalectomy improved weight control and diabetes control (both P=0.002) compared with the control group.

Comment: Good evidence upon which to base treatment in these patients.