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Three-year outcomes of oral antibiotics vs intravenous and oral antibiotics for uncomplicated acute appendicitis. A secondary analysis of the APPAC II randomized clinical trial.

3 November 2024
Randomized clinical trials Colorectal
Selänne L, Haijanen J, Sippola S, Hurme S, Rautio T, Nordström P et al.
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BJS-2024-0134
Randomized clinical trials
Colorectal
Three-year outcomes of oral antibiotics vs intravenous and oral antibiotics for uncomplicated acute appendicitis. A secondary analysis of the APPAC II randomized clinical trial.
Selänne L, Haijanen J, Sippola S, Hurme S, Rautio T, Nordström P et al.
03 11 2024
JAMA Surg 2024; 159: 727-735.
There was no difference in short term outcomes in the original RCT that included 582 patients. After 3 years, treatment success (no recurrence of appendicitis) rates were also similar in both groups.
Comment: Reasonable to use oral antibiotics alone for uncomplicated appendicitis.
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Published on: 3 November 2024
Article ID: BJS-2024-0134

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