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Short-term outcomes of Early versus conventional adjuvant chemotherapy in stage III colon cancer: randomized clinical trial. 

Lee KH, Park SY, Song SH, Kim HJ, Kim JG, Kang BW et al.

BJS Open 2023; 7: zrad064.

This study included 443 patients. Toxicity rates were similar in those randomized to early chemotherapy two weeks after surgery compared to standard intervention.

Comment: Starting chemotherapy over eight weeks after surgery is detrimental. This study suggests there is no harm (and may be benefit) in starting it two weeks after surgery.

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