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PACE: randomized, controlled, multicentre, multinational, phase III study of PLX-PAD for critical limb ischaemia in patients unsuitable for revascularization: randomized clinical trial

Norgren L, Weiss N, Nikol S, Lantis JC, Patel MR, Hinchliffe RJ et al.

Br J Surg 2024; 111:  znad437.

This study included 143 patients with limb-threatening ischaemia, unsuitable for standard treatment. Intramuscular injections of placental-derived mesenchymal cells, 60 days apart did not affect amputation-free survival: 28.6 per cent, versus 33 per cent with placebo. The effect was more positive in non-diabetics.

Comment: Interesting subgroup analysis that may be the basis for further study.

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