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Extended-course antibiotic prophylaxis in lower limb amputation: randomized clinical trial.

Souroullas P, Barnes R, Carradice D, Smith G, Huang C, Chetter I.

Br J Surg 2022; 109: 426-432.

In this study that included 152 procedures, the five day course reduced the rate of surgical site infection (11.8 versus 39.5 per cent, P<0.001) and revisional surgery (6.6 versus 21 per cent, P=0.01).

Comment: Is this now the standard of care?

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