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Effect of prucalopride to improve time to gut function recovery following elective colorectal surgery: randomized clinical trial.


Milne T, Liu C, O’Grady G, Woodfield J, Bissett I. 

Br J Surg 2022; 109: 704–710.

Return of gut function was not improved by prucalopride, a serotonin agonist, 2 mg given before surgery and 2 mg daily for six days, in this study that included 148 patients.

Comment: Disappointing.

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