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Nonoperative vs operative management of uncomplicated acute appendicitis. A systematic review and meta-analysis.
17 November 2022
Randomized clinical trials Lower GI
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Comment: But will it affect cancer outcomes in the longer term?
Sixty-day mortality of patients with metastatic colorectal cancer randomized to systemic treatment vs primary tumor resection followed by systemic treatment. The CAIRO4 phase 3 randomized clinical trial.
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Comment: These results are of interest, but the real question is whether additional surgery provides a later benefit.
End colostomy with or without mesh to prevent a parastomal hernia (GRECCAR 7). A prospective, randomized, double blinded, multicentre trial.
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Comment: It is interesting that there have been numerous RCTs, but with very variable results. This makes it difficult to conduct a systematic analysis, and to provide definitive recommendations.
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