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Effect of lower extremity nerve decompression in patients with painful diabetic peripheral neuropathy. The diabetic neuropathy nerve decompression randomized, observation group and placebo surgery–controlled clinical trial

6 December 2024
Randomized clinical trials Vascular
BJSA
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
Rozen S, Wolfe G, Vernino S, Raskin P, Hynan LS, Wyne K et al.
Ann Surg 2024; 280: 35-45.
This double blind RCT included 78 patients with painful neuropathy for over one year. Mean pain scores were reduced after decompression surgery, and to a lesser extent by sham surgery after 12 months compared to controls. The difference between decompressed and sham operated legs was significant at five years, P=0.0002.
Comment: Complex area, and more work needed to determine whether surgery has a role.
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