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Short-term outcomes following laparoscopic vs open pancreaticoduodenectomy in patients with pancreatic ductal adenocarcinoma. A randomized clinical trial.


Wang M, Pan S, Qin T, Xu X, Huang X, Liu J et al.

JAMA Surg 2023; 158: 1245-1253. 

Among 412  eligible patients, 200 were randomized. Laparoscopic surgery took longer (330 versus 297 min, P<0.001), and resulted in lower median blood loss (145 versus 200ml, P=0.02), but overall complication rates and hospital stay were similar. Only two patients died within 90 days, both in the laparoscopic group.

Comment: Differences in outcomes surprisingly small.

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