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Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.


Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G et al, on behalf of the BIG 3–07/TROG 07.01 trial investigators.

Lancet 2022; 400: 431-440.

This multicentre study included 1608 patients in a two by two design. The five-year freedom from recurrence rate was higher after booster radiotherapy (97.1 versus 92.7 per cent, P<0.001), but with higher rates of breast pain and induration.

Comment: Booster radiotherapy improved local control, and women can be warned concerning the after effects.

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