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Occurrence of breast-cancer–related lymphedema after reverse lymphatic mapping and selective axillary dissection versus standard surgical treatment of axilla: A two-arm randomized clinical trial.


Massimimiliano G, Maccauro M, Mariani L, Listorti C, Sigari C, De Vivo A et al.

Cancer 2022; 128: 4185-4193.

Reverse axillary mapping with selective axillary dissection reduced the rate of lymphoedema by 21 per cent (confidence intervals 3-37 per cent, P=0.03) in this study that included 130 patients. Self-reported rates of lymphoedema were not different between the groups.

Comment; Disappointing that the women did not notice a difference.

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