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Laparoscopic versus open pancreatoduodenectomy in patients with periampullary tumors. A systematic review and meta-analysis

Sattari SA, Sattari AR, Makary MA, Hu C, He J.

Ann Surg 2023; 277: 742-755.

Four RCTs including 818 procedures were studied. The laparoscopic procedure took longer, but was associated with less blood loss, fewer surgical site infections and reduced length of hospital stay: mean 2.5 days, P=0.06.

Comment: this is a common result for laparoscopic versus open surgery studies, but a definitive comparison includes late outcomes in cancer cases, and costs (see also Pfister et al).

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