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Implementation of best practices in pancreatic cancer care in the Netherlands. A stepped-wedge randomized clinical trial.


Mackay TM, Latenstein AEJ, Augustinus S, van der Geest LG, Bogte A et al, for the Dutch Pancreatic Cancer Group.

JAMA Surg 2024; 159: 429-437.

This study included 5887 patients with pancreatic cancer. One year survival was similar both before and after implementation of a best practice protocol (24 versus 23 per cent). Most patients did not receive any tumour-directed therapy.

Comment: I like that this study has a negative primary result, but shows up how much care for pancreatic cancer is palliative. It will stimulate discussion about how to offer more active therapy.

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