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Goal-directed perioperative albumin substitution versus standard of care to reduce postoperative complications. A randomized clinical trial (SuperAdd Trial).

Schaller S, Fuest K, Ulm B, Schmid S, Bubb C, Eckstein H-H et al.

Ann Surg 2024; 279: 402-409.

Some 2509 patients having high-risk, non-cardiac surgery with low serum albumin postoperatively were randomized to albumin substitution or treatment only in an emergency. Complication rates were unaffected by the albumin treatment: 84.7 versus 87.3 Percent in controls.

Comment: Another attempt to support albumin treatment in the acute situation fails. It remains unclear why.

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