Join BJS Academy
BJS Academy>Randomized clinical ...>Five year outcomes o...
Normal View Dyslexic View

Five-year outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial.

24 November 2022
Randomized clinical trials Vascular
Lindholt JS, Sogaard R, Rasmussen LM, Mejldal A, Lambrechtsen J, Steffensen FH et al.

N Engl J Med 2022; 387: 1385-1394.

Some 46,611 men were randomized. After five years, intention to treat analyses showed no difference in overall mortality rate compared to controls: hazard ratio 0.95, 95 per cent confidence interval 0.9 to 1.0, P=0.06. There was no significant reduction in the rates of stroke, myocardial infarction or aortic aneurysm rupture.

Comment; This is a very disappointing result after the same authors’ previous study showed a significant mortality reduction. It’s back to the drawing board for cardiovascular screening.

BJS Foundation Limited
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
rct170
Randomized clinical trials
Randomized clinical trials
Vascular
Five-year outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial.
Lindholt JS, Sogaard R, Rasmussen LM, Mejldal A, Lambrechtsen J, Steffensen FH et al.
24112022
N Engl J Med 2022; 387: 1385-1394.
Some 46,611 men were randomized. After five years, intention to treat analyses showed no difference in overall mortality rate compared to controls: hazard ratio 0.95, 95 per cent confidence interval 0.9 to 1.0, P=0.06. There was no significant reduction in the rates of stroke, myocardial infarction or aortic aneurysm rupture.
Comment; This is a very disappointing result after the same authors’ previous study showed a significant mortality reduction. It’s back to the drawing board for cardiovascular screening.
Published on: 24 November 2022
Article ID: rct170

Related articles

Covered versus bare-metal stenting of the mesenteric arteries in patients with chronic mesenteric ischaemia (CoBaGI): a multicentre, patient-blinded and investigator-blinded, randomised controlled trial.

Terlouw LG, van Dijk LJD, van Noord D, Bakker OJ, Bijdevaate DC, Erler NS et al, on behalf of the Dutch Mesenteric Ischemia Study Group.

16 August 2024

Ten-year outcomes of a randomized clinical trial of endothermal ablation versus conventional surgery for great saphenous varicose veins

Mohamed AH, Howitt A, Rae S, Cai PL, Hitchman L, Wallace T et al.

18 September 2024

Effect of anticoagulant therapy for 6 weeks vs 3 months on recurrence and bleeding events in patients younger than 21 years of age with provoked venous thromboembolism. The Kids-DOTT randomized clinical trial.

Goldenberg NA, Kittelson JM, Abshire TC, Bonaca M, Casella JF, Dale RA et al, for the Kids-DOTT Trial investigators and the ATLAS Group.
JAMA 2022; 327: 129-137.

1 February 2022
Home
  • Normal view
  • Dyslexic view
Info
Copied!