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Five-year outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial.

Lindholt JS, Sogaard R, Rasmussen LM, Mejldal A, Lambrechtsen J, Steffensen FH et al.

N Engl J Med 2022; 387: 1385-1394.

Some 46,611 men were randomized. After five years, intention to treat analyses showed no difference in overall mortality rate compared to controls: hazard ratio 0.95, 95 per cent confidence interval 0.9 to 1.0, P=0.06. There was no significant reduction in the rates of stroke, myocardial infarction or aortic aneurysm rupture.

Comment; This is a very disappointing result after the same authors’ previous study showed a significant mortality reduction. It’s back to the drawing board for cardiovascular screening.

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