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Effect of telmisartan on walking performance in patients with lower extremity peripheral artery disease. The TELEX Randomized Clinical Trial.
24 November 2022
Randomized clinical trials Vascular
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Covered versus bare-metal stenting of the mesenteric arteries in patients with chronic mesenteric ischaemia (CoBaGI): a multicentre, patient-blinded and investigator-blinded, randomised controlled trial.
Terlouw LG, van Dijk LJD, van Noord D, Bakker OJ, Bijdevaate DC, Erler NS
Lancet Gastrohepatol 2024; 9: 299-309.
Ninety-four patients with chronic mesenteric ischaemia were included. Only one patient died. After 24 months, the patency of covered stents was better than bare metal stents: 81 versus 49 per cent, P<0.0001. Access site adverse events were more common in covered stent procedures.
Comment: This study does not address whether symptoms were improved alongside patency.
Ten-year outcomes of a randomized clinical trial of endothermal ablation versus conventional surgery for great saphenous varicose veins
Mohamed AH, Howitt A, Rae S, Cai PL, Hitchman L, Wallace T
Br J Surg 2024; 111: znae195.
Some 206 of the original 280 patients were available for analysis. Both procedures resulted in durable improvements in disease-specific quality of life (P<0.001). Clinical recurrence was lower after endothermal ablation: 37 versus 59 per cent, P=0.005.
Comment: Endothermal ablation has real long term advantages.
Effect of anticoagulant therapy for 6 weeks vs 3 months on recurrence and bleeding events in patients younger than 21 years of age with provoked venous thromboembolism. The Kids-DOTT randomized clinical trial.
JAMA 2022; 327: 129-137.
Some 417 patients under 21 years of age were included. Rates of recurrent venous thromboembolism were similarly low after both treatments: 0.66 per cent after six weeks of versus 0.7 per cent after three months of anticoagulation.
Comment: Very low recurrence rates, but six weeks of anticoagulation seems reasonable.
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