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Effect of microdoses of incisional antibiotics on the rate of surgical site infections in skin cancer surgery. A randomized clinical trial.


Goh M, Hollewand C, McBride S, Ryan N, van der Werf B, Mathy JA.

JAMA Surg 2023; 158: 718-726.

Some 661 patients having minor skin surgery were randomized to incision site injection of one of two antibiotics, or local anaesthetic alone. Significant wound infection occurred in 5.7 per cent of controls, 5.3 per cent with Flucloxacillin and 2.1 per cent with Clindamycin (P=0.01 vs controls).

Comment: No mention whether this strategy is cost effective.

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