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Effect of a home-based, walking exercise behavior change intervention vs usual care on walking in adults with peripheral artery disease. The MOSAIC randomized clinical trial.


Bearne M, Volkmer B, Sekhon M, Fisher G, Galea Homes MN, Douiri A, et al for the MOSAIC Trial Collaboration.

JAMA 2022; 327: 1344-1355.

The study included 190 participants randomly allocated to a walking exercise behaviour change intervention by physiotherapists. After three months, those who had received the intervention had an improved 6-minute walking test by around 30m (P=0.009).

Comment: The questions remain whether this improvement is meaningful and durable.

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