Leong T, Smithers BM, Michael M, Haustermans K, Wong R, Gebski V et al, for the Australasian Gastro-Intestinal Trials Group, National Health and Medical Research Council Clinical Trials Centre, Trans-Tasman Radiation Oncology Group, European Organisation for Research and Treatment of Cancer, and Canadian Cancer Trials Group.
N Engl J Med 2024; 391: 1810-1821.
Some 574 patients were randomized to preoperative radiotherapy, in addition to perioperative chemotherapy. After median follow-up of 67 months, the addition of radiotherapy did not improve survival: 46 months compared to 49 months with chemotherapy alone.
Comment: There does not appear to be a role for radiotherapy in these patients.
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