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Laparoscopic pylorus-preserving gastrectomy versus distal gastrectomy for early gastric cancer. A multicenter randomized controlled trial (KLASS-04)

10 September 2025
Upper GI
BJSA
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
Lee HK, Kim Y-W, Park DJ, Han SU, Ryu KW, Kim H-H et al.
Ann Surg 2025; 281: 573-581.
Some 256 patients were included and followed for three years; only one patient in each group had recurrent cancer. Quality of life and body weight were similar in both groups. Pylorus preservation improved haemoglobin and protein levels, and reduced the risk of gallstones, but increased reflux oesophagitis and delayed gastric emptying.
Comment: No clear winner, but reassuringly low rates of recurrence, so symptoms important.
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