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Efficacy and safety of REGN9933A2 and REGN7508Cat for preventing postoperative venous thromboembolism (ROXI-VTE-I and ROXI-VTE-II): two randomised, open-label, phase 2 trials

9 January 2026
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Efficacy and safety of REGN9933A2 and REGN7508Cat for preventing postoperative venous thromboembolism (ROXI-VTE-I and ROXI-VTE-II): two randomised, open-label, phase 2 trials
09012026
Weitz JI, Kithcart AP, O’Brien MP, Levy O, Marin E, Onisko M et al. 
Lancet 2025; 406: 2551-2563.
These two RCTs included over 550 patients undergoing knee replacement. Compared with Fragmin, only REGN7508Cat (an antibody that binds to the catalytic domain of Factor XI) was superior: mean adjusted odds ratio 0.37, 95 per cent confidence interval 0.2 to 0.68.
Comment: The science of anticoagulation progresses.
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Published on: 9 January 2026
Article ID: BJS-2026-0011

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