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De-escalated neoadjuvant weekly nab-paclitaxel with trastuzumab and pertuzumab versus docetaxel, carboplatin, trastuzumab, and pertuzumab in patients with HER2-positive early breast cancer (HELEN-006): a multicentre, randomised, phase 3 trial

11 July 2025
Breast
BJSA
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
Chen X-C, Jiao D-C, Qiao J-H, Wang C-Z, Sun X-F, Lu Z-D et al.
Lancet Oncol 2025; 26: 27-36.
Some 689 women were included in the study. The new regimen improved the rate of pathological complete response compared with standard neoadjuvant chemotherapy (66.3 versus 57.6 per cent, P=0.011), without increasing the rate of adverse events.
Comment: Higher complete response rate may improve survival.
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