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Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial

6 March 2025
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BJS-2025-0347
Randomized clinical trials
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Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial
06032025
St Peter SD, Noel-MacDonnell JR, Hall NJ, Eaton S, Suominen JS, Wester T et al.
Lancet 2025; 405: 233-240.
Some 936 children with non-perforated appendicitis were included in this study and followed for twelve months. Antibiotic management was inferior to surgery; treatment failure occurred in 34 per cent of the antibiotic group and 7 per cent after appendicectomy. There were no serious adverse events in either group.
Comment: Large multicentre study that concludes surgery remains the treatment of choice in children.
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Published on: 6 March 2025
Article ID: BJS-2025-0347

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