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Tranexamic acid in patients undergoing noncardiac surgery.

13 July 2022
Randomized clinical trials General
Devereaux PJ, Marucci M, Painter TW,  Conen D, Lomivorotov V, Sessler DI et al, for the POISE-3 Investigators.

N Engl J Med 2022; 386: 1986-1997.

A total of 9535 procedures were studied. Tranexamic acid reduced bleeding complications (11.7 versus 9.1 per cent, P<0.001), but slightly increased the risk of cardiovascular complications (14.2 versus 13.9 per cent, P=0.04).

Comment: Is the trade-off worth it, except for specific procedures with high blood loss?

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rct210
Randomized clinical trials
Randomized clinical trials
General
Tranexamic acid in patients undergoing noncardiac surgery.
Devereaux PJ, Marucci M, Painter TW,  Conen D, Lomivorotov V, Sessler DI et al, for the POISE-3 Investigators.
13072022
N Engl J Med 2022; 386: 1986-1997.
A total of 9535 procedures were studied. Tranexamic acid reduced bleeding complications (11.7 versus 9.1 per cent, P<0.001), but slightly increased the risk of cardiovascular complications (14.2 versus 13.9 per cent, P=0.04).
Comment: Is the trade-off worth it, except for specific procedures with high blood loss?
Published on: 13 July 2022
Article ID: rct210

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