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Tranexamic acid in patients undergoing noncardiac surgery.

Devereaux PJ, Marucci M, Painter TW,  Conen D, Lomivorotov V, Sessler DI et al, for the POISE-3 Investigators.

N Engl J Med 2022; 386: 1986-1997.

A total of 9535 procedures were studied. Tranexamic acid reduced bleeding complications (11.7 versus 9.1 per cent, P<0.001), but slightly increased the risk of cardiovascular complications (14.2 versus 13.9 per cent, P=0.04).

Comment: Is the trade-off worth it, except for specific procedures with high blood loss?

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