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Tranexamic acid and blood loss in pancreaticoduodenectomy: TAC-PD randomized clinical trial

Ishii K, Yokoyama Y, Yonekawa Y, Hayashi D, Kinoshita F, Kuwatsuka Y et al.

Br J Surg 2023; 110: 159–165.

This trial that included 218 procedures did not show any difference in intra-operative blood loss with (mean 695ml), or without tranexamic acid (667 ml). Other secondary outcomes were also similar.

Comment: Surprising, since tranexamic acid does seem to be beneficial in most operations with significant blood loss.

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