Join BJS Academy
BJS Academy>Randomized clinical ...>Tranexamic acid and ...
Normal View Dyslexic View

Tranexamic acid and blood loss in pancreaticoduodenectomy: TAC-PD randomized clinical trial

6 March 2023
Randomized clinical trials HPB
Ishii K, Yokoyama Y, Yonekawa Y, Hayashi D, Kinoshita F, Kuwatsuka Y et al.

Br J Surg 2023;110: 159–165.

This trial that included 218 procedures did not show any difference in intra-operative blood loss with (mean 695ml), or without tranexamic acid (667 ml). Other secondary outcomes were also similar.

Comment: Surprising, since tranexamic acid does seem to be beneficial in most operations with significant blood loss.

BJS Foundation Limited
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
rct139
Randomized clinical trials
Randomized clinical trials
HPB
Tranexamic acid and blood loss in pancreaticoduodenectomy: TAC-PD randomized clinical trial
Ishii K, Yokoyama Y, Yonekawa Y, Hayashi D, Kinoshita F, Kuwatsuka Y et al.
06032023
Br J Surg 2023;110: 159–165.
This trial that included 218 procedures did not show any difference in intra-operative blood loss with (mean 695ml), or without tranexamic acid (667 ml). Other secondary outcomes were also similar.
Comment: Surprising, since tranexamic acid does seem to be beneficial in most operations with significant blood loss.
Published on: 6 March 2023
Article ID: rct139

Related articles

Temporary portocaval shunt provides superior intraoperative hemodynamics and reduces blood loss and duration of surgery in live donor liver transplantation. A randomized controlled trial.

Kumar M, Patil NS, Mohapatra N, Sindwani G, Dhingra U, Yadav A et al.
Ann Surg 2024; 279: 932-944.

16 August 2024

Upfront endoscopic necrosectomy or step-up endoscopic approach for infected necrotising pancreatitis (DESTIN): a single-blinded, multicentre, randomised trial.

Bang JY, Lakhtakia S, Thakkar S, Buxbaum JL, Waxman I, Sutton B et al, on behalf of the United States Pancreatic Disease Study Group.

16 August 2024

Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial.

Labori KJ, Bratlie SO, Andersson B, Angelsen J-H, Biorserud C, Bjornsson B et al, for the Nordic Pancreatic Cancer Trial-1 study group.

30 August 2024
Home
  • Normal view
  • Dyslexic view
Info
Copied!