Presurgical oral tamoxifen vs transdermal 4-hydroxytamoxifen in women with ductal carcinoma in situ. A randomized clinical trial.
Khan SA, Mi X, Blanco Jr LZ, Akasha AM, Pilewskie M, Degnim AC et al.
JAMA Surg 2023;158: 1265-1273.
In this trial that included 75 evaluable patients, use of tamoxifen gel on the breast skin did not have similar biochemical changes to use of oral tamoxifen preoperatively. In addition the DCIS score decreased more with oral tamoxifen.
Comment: This formulation is not an acceptable alternative to Tamoxifen tablets.
13 February 2024
Read paperAcademy
Part of the charitable activity of the Foundation, BJS Academy is an online educational resource for current and future surgeons.
The Academy is comprised of five distinct sections: Continuing surgical education, Young BJS, Cutting edge, Scientific surgery and Surgical news. Although the majority of this is open access, additional content is available to BJS subscribers and strategic partners.
