Effect of total breast reconstruction with autologous fat transfer using an expansion device vs implants on quality of life among patients with breast cancer. A randomized clinical trial.

Piatkowski AA, Wederfoort JLM, Hommes JE, Schop SSJ, Krastev TK, van Kuijk SMJ et al, for the Breast Reconstruction With External Preexpansion & Autologous Fat Transfer vs Standard Therapy (BREAST) Trial Investigators.

JAMA Surg 2023; 158: 456-464.

There was no evidence that fat transfer was unsafe in this study that included 193 women. Quality of life was improved in all five domains in women who had the fat transfer procedure in the 132 women who completed the study (all domains P<0.05). There were no differences in complications or oncological outcomes.

Comment: Less invasive than breast reconstruction.