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Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial.


Qin S, Chen M, Cheng A-L, Kaseb AO, Kudo M, Lee HC et al, for the IMbrave50 investigators.

Lancet 2023; 402: 1835-1847.plus

In this study that included 668 patients followed for a median of 17.4 months, adjuvant treatment improved recurrence-free survival: hazard ratio 0.72, 95 per cent confidence interval 0.53 to 0.98, P=0.012.

Comment: Among the first to show a benefit from adjuvant treatment with immunotherapy.

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