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A systematic review and meta-analysis of randomized controlled trials comparing intraoperative red blood cell transfusion strategies.


Lenet T, Baker L, Park L, Vered M, Zahrai A, Shorr R et al.

Ann Surg 2022; 275: 456-466.

Fourteen trials including 8641 procedures were studied. A restrictive blood transfusion policy did reduce the volume of blood transfused without increasing postoperative morbidity. Two of the trials did show adverse composite outcomes for restrictive transfusion.

Comment: The result isn’t definitive, but further evidence that restrictive transfusion is generally not harmful.

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