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Individualised neoantigen therapy mRNA-4157 (V940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (KEYNOTE-942): a randomised, phase 2b study.

3 May 2024
Randomized clinical trials General
Weber JS, Carlino MS, Khattak A, Meniawy T, Ansstas G, Taylor MH et al.

Lancet 2024; 403: 632-644. 

This study included 157 patients with high risk of recurrence after surgical resection. After eighteen months, the addition of neoantigen therapy improved recurrence-free survival from 62 to 79 per cent, P=0.053. There were no serious side effects. 

Comment: The start of vaccination therapy for melanoma. 

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rct021
Randomized clinical trials
Randomized clinical trials
General
Individualised neoantigen therapy mRNA-4157 (V940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (KEYNOTE-942): a randomised, phase 2b study.
Weber JS, Carlino MS, Khattak A, Meniawy T, Ansstas G, Taylor MH et al.
03052024
Lancet 2024; 403: 632-644. 
This study included 157 patients with high risk of recurrence after surgical resection. After eighteen months, the addition of neoantigen therapy improved recurrence-free survival from 62 to 79 per cent, P=0.053. There were no serious side effects. 
Comment: The start of vaccination therapy for melanoma. 
Published on: 3 May 2024
Article ID: rct021

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