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Effect of the use of reinforced stapling on the occurrence of pancreatic fistula after distal pancreatectomy. Results of the REPLAY (REinforcement of the Pancreas in distaL pAncreatectomY) multicenter randomized clinical trial.


Merdrignac A, Garnier J, Dokmak S, Regenet N, Lesurtel M, Mabrut JY, et al.

Ann Surg 2022; 276: 769-775.

Use of the reinforced stapler actually increased the overall rate of pancreatic fistula compared to the standard device: 83 versus 67.7 per cent (P=0.021), in this study that included 199 procedures. The rates of clinically relevant fistula and other complications was similar.

Comment: Disappointing results.

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