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Preoperative high dose of dexamethasone in emergency laparotomy: randomized clinical trial

10 September 2024
Randomized clinical trials General
Cihoric M, Kehlet H, Lauritsen ML, Højlund J, Kanstrup K, Kärnsund S et al.  

Br J Surg 2024; 111: znae130.

A single dose of dexamethasone given at the start of emergency laparotomy reduced the mean C-reactive protein level after 24h from  220 to 170 mg/l, P=0.015. It also reduced postoperative major complications (27 versus 45 per cent, P=0.032) and 90-day mortality (7 versus 23 per cent, P=0.023).

Comment: Is there enough evidence yet for this to be the standard of care?

Read comment onRead author response

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rct264
Randomized clinical trials
Randomized clinical trials
General
Preoperative high dose of dexamethasone in emergency laparotomy: randomized clinical trial
Cihoric M, Kehlet H, Lauritsen ML, Højlund J, Kanstrup K, Kärnsund S et al.  
10092024
Br J Surg 2024; 111: znae130.
A single dose of dexamethasone given at the start of emergency laparotomy reduced the mean C-reactive protein level after 24h from  220 to 170 mg/l, P=0.015. It also reduced postoperative major complications (27 versus 45 per cent, P=0.032) and 90-day mortality (7 versus 23 per cent, P=0.023).
Comment: Is there enough evidence yet for this to be the standard of care?
Read comment onRead author response
Published on: 10 September 2024
Article ID: rct264

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