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Efficacy and safety of intraoperative hyperthermic intraperitoneal chemotherapy for locally advanced colon cancer. A phase 3 randomized clinical trial.


Arjona-Sánchez A, Espinosa-Redondo E, Gutiérrez-Calvo A, Segura-SampedroJJ, Pérez-Viejo E, Concepción-Martin V et all for the Grupo Español de Carcinomatosis Peritoneal.

JAMA Surg 2023; 158: 683-691. 

A total of 184 patients underwent cytoreductive surgery with or without HIPEC. The three year locoregional control rate was improved by additional HIPEC: 97.6 versus 87.6 per cent, P=0.03. Disease-free survival was similar between the groups. Patients with stage pT4 disease were particularly advantaged.

Comment: Data to help identify those who will benefit most.

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