Aspirin chemoprevention in colorectal cancer: network meta-analysis of low, moderate, and high doses.
Shah D, Di Re A, Toh JWT.
Br J Surg 2023; 110: 1691-1702.
Thirteen trials (ten RCTs) were included in the analysis of almost 100,000 participants. Low and medium dose aspirin had no significant effect, but high dose aspirin (500-1200mg/day) reduced the risk of colon cancer: odds ratio 0.69, 95 per cent credible interval 0.5 to 0.96.
Comment: the higher dose of aspirin comes with risks, so although interesting, unlikely to be widely used.
24 January 2024
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