Short-term anti-TNF therapy with surgical closure versus anti-TNF therapy in the treatment of perianal fistulas in Crohn’s disease (PISA-II): a patient preference randomised trial.
Meima-van Praag LM, van Rijn KL, Wasmann KAT, Snijder H, Stoker J, D’Haens GR et al.
Lancet Gastroenterol Hepatol 2022; 7: 617-626.
Some 95 patients were included in this trial. After 18 months, radiological (MRI) healing was higher after surgery with anti-TNF (32 per cent) than anti-TNF alone (9 per cent); P=0.005. In contrast, clinical closure rates were reported as similar: 68 versus 52 per cent, respectively.
Comment: Shouldn’t there have been a surgery only arm for the perfect trial?
6 September 2022Read paper
Part of the charitable activity of the Society, BJS Academy is an online educational resource for current and future surgeons.
The Academy is comprised of five distinct sections: Continuing surgical education, Young BJS, Cutting edge, Scientific surgery and Surgical news. Although the majority of this is open access, additional content is available to BJS subscribers and strategic partners.