Pyridostigmine to reduce the duration of postoperative Ileus after colorectal surgery (PyRICo-RCT): randomized clinical trial.
Traeger L, Bedrikovetski S, Fitzsimmons T, Nguyen T-M, Moore JW, Lewis M et al.
Br J Surg 2024; 111: znae121.
Pyridostigmine 60mg given orally twice daily after surgery reduced the duration of ileus by one day, measured by the GI-2 tool (P=0.015) in this study that included 130 patients, but did not affect the duration of hospital stay.
Comment: Apart from speeding return of bowel function, it is not clear what the benefit is overall.
7 August 2024
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