Morbidity after mechanical bowel preparation and oral antibiotics prior to rectal resection. The MOBILE2 randomized clinical trial.
Koskenvuo L, Lunkka P, Varpe P, Hyoty M, Satokari R, Haapamaki C et al.
JAMA Surg 2024; 159: 606-614.
In this study that included 565 procedures, the addition of oral antibiotics reduced the rate of surgical site infections (odds ratio 0.45, 95 per cent confidence interval 0.27 to 0.77) and anastomotic leaks (0.39, 0.21 to 0.72).
Comment: The authors suggest this should be the standard of care.
25 September 2024
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