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Effect of colonoscopy screening on risks of colorectal cancer and related death.

24 November 2022
Randomized clinical trials Lower GI
Bretthauer M, Loberg M, Wieszcy P, Kalager M, Emilsson L, Garborg K et al, for the NordICC Study Group.

N Engl J Med 2022; 387: 1547-1556.

This study included over 84,000 people aged 55 to 64. A single colonoscopy reduced the risk of colorectal cancer by 18% after 10 years (number needed to screen to prevent one colorectal cancer = 455). The risk of death from colorectal cancer and the overall risk of death was not significantly reduced by screening.

Comment: As is so often the case with screening programmes, they can be shown to reduce the rate of the specific condition, but not mortality.

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rct169
Randomized clinical trials
Randomized clinical trials
Lower GI
Effect of colonoscopy screening on risks of colorectal cancer and related death.
Bretthauer M, Loberg M, Wieszcy P, Kalager M, Emilsson L, Garborg K et al, for the NordICC Study Group.
24112022
N Engl J Med 2022; 387: 1547-1556.
This study included over 84,000 people aged 55 to 64. A single colonoscopy reduced the risk of colorectal cancer by 18% after 10 years (number needed to screen to prevent one colorectal cancer = 455). The risk of death from colorectal cancer and the overall risk of death was not significantly reduced by screening.
Comment: As is so often the case with screening programmes, they can be shown to reduce the rate of the specific condition, but not mortality.
Published on: 24 November 2022
Article ID: rct169

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