Join BJS Academy
BJS Academy>Randomized clinical ...>Trimodality therapy ...
Normal View Dyslexic View

Trimodality therapy versus perioperative chemotherapy in  the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (NEO-AEGIS): an open-label, randomised, phase 3 trial.

24 January 2024
Randomized clinical trials Upper GI
Reynolds JV, Preston SR, O’Neill B, Lowery MA, Baeksgaard  L, Crosby T et al, on behalf of the Neo-AEGIS Investigators and trial group.

Lancet Gastrohepatol 2023; 8: 1015-1027.

Some 362 patients were available for analysis after a median of 38.8 months. Overall survival was 48 months after perioperative chemotherapy versus 49.2 months after trimodality therapy; hazard ratio 1.03, 95 per cent confidence interval 0.77 to 1.38; P=0.82.

Comment: Disappointing result, and calls into question the role of radiotherapy for this condition.

BJS Foundation Limited
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
rct049
Randomized clinical trials
Randomized clinical trials
Upper GI
Trimodality therapy versus perioperative chemotherapy in  the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (NEO-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O’Neill B, Lowery MA, Baeksgaard  L, Crosby T et al, on behalf of the Neo-AEGIS Investigators and trial group.
24012024
Lancet Gastrohepatol 2023; 8: 1015-1027.
Some 362 patients were available for analysis after a median of 38.8 months. Overall survival was 48 months after perioperative chemotherapy versus 49.2 months after trimodality therapy; hazard ratio 1.03, 95 per cent confidence interval 0.77 to 1.38; P=0.82.
Comment: Disappointing result, and calls into question the role of radiotherapy for this condition.
Published on: 24 January 2024
Article ID: rct049

Related articles

Randomized clinical trial on D2 lymphadenectomy versus D2 lymphadenectomy plus complete mesogastric excision in patients undergoing gastrectomy for cancer (DCGC01 study).

Xie D, Shen J, Liu L, Cao B, Xiao A, Qin J et al.

7 August 2024

Multicentre randomized clinical trial on robot-assisted versus video-assisted thoracoscopic oesophagectomy (REVATE trial).

Chao Y-K, Li Z, Jiang H, Wen Y-W, Chiu C-H, Li B et al.

7 August 2024

Assessment of laparoscopic indocyanine green tracer-guided lymphadenectomy after neoadjuvant chemotherapy for locally advanced gastric cancer. A randomized controlled trial.

Huang Z-N, Tang Y-H, Zhong Q, Li P, Xie J-W, Wang J-B et al.

30 August 2024
Home
  • Normal view
  • Dyslexic view
Info
Copied!